Seven Bridges is committed to providing the Platform users with the most up-to-date version of the TARGET GRCh38 dataset that is available from the NCI Genomic Data Commons (GDC). In keeping with this commitment, the Seven Bridges Platform transitioned from hosting version 11.0 of this dataset to version 14.0 on February 11, 2019. (See the GDC Release Notes for details of the changes).
As of this date, all files accessible via the Data Browser, the API, and SPARQL queries correspond to Data Release 14.0. Files that were added to individual projects before this date and are no longer represented in Data Release 14.0 will be made available for 30 days following the update, after which they no longer be accessible via those projects but may be obtainable from the GDC archive by contacting the GDC Help Desk.
Similarly, files that are no longer represented in Data Release 11.0 are no longer accessible through saved Data Browser queries, and affected queries will return a result of '0'.
In addition, due to a change in the way some files within this dataset are hosted, a small number of saved Data Browser queries for which the files are still available also will return a '0' result. Such queries can be recreated using the Data Browser query-building canvas and will continue to return the same results as previously.
Please contact [email@example.com] if you have any questions. The Seven Bridges Team looks forward to continuing to collaborate with the GDC in the months ahead to ensure the timely availability through the Seven Bridges Platform of new data releases for this dataset.
The Therapeutically Applicable Research to Generate Effective Treatments (TARGET) dataset was generated by a diverse consortium of investigators to facilitate the discovery of genetic changes that underlie the development and progression of childhood cancers for which there currently are limited treatment options. The initiative is jointly managed within the National Cancer Institute (NCI) by the Office of Cancer Genomics (OCG) and the Cancer Therapy Evaluation Program (CTEP) and builds upon the resources of several other high-profile NCI cancer genomics programs, including The Cancer Genome Atlas (TCGA), the Cancer Genome Characterization Initiative (CGCI), and the Strategic Partnership to Evaluate Cancer Signatures (SPECS). The majority of TARGET project teams are associated with the Children’s Oncology Group (COG), an NCI clinical trials program that focuses exclusively on research into childhood and adolescent cancers.
The TARGET project first consisted of two pilot programs that generated genomic and transcriptomic data from patients with high-risk subtypes of acute lymphoblastic leukemia (ALL) and neuroblastoma (NBL). The dataset has since been expanded to encompass data collected using a variety of sequencing and array-based methods to examine the genomes, transcriptomes, and epigenomes of patients representing subtypes of acute myeloid leukemia, osteosarcoma, and select kidney tumors as well as additional subtypes of ALL and NBL.
For a full list of TARGET data available on the Platform, see the table below. The table details data categories and types, the data format of data subtypes, and the access level of each data type. Note that TARGET contains Open Data and Controlled Data. Learn more about data access levels.
Learn more about the metadata for the TARGET dataset.